Anti-GABRE antibody (STJ96433)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human GABthe amino acid range R Epsilon.
General Information
| Short Description | Rabbit polyclonal anti-Gamma-aminobutyric acid receptor subunit epsilon receptor subunit epsilon for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GABRE |
| Gene ID | 2564 |
| Uniprot ID | GBRE_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human GABthe amino acid range R Epsilon. |
| Specificity | GABAA R Epsilon Polyclonal Antibody detects endogenous levels of GABAA R Epsilon protein. |
Additional Info
| Function | Epsilon subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing epsilon subunits also permit spontaneous chloride channel activity while preserving the structural information required for GABA-gated openings. GABARs containing epsilon subunit may regulate cardiac function (Probable). |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit EpsilonGaba(A Receptor Subunit EpsilonGabaar Subunit Epsilon |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Epsilon antibodyAnti-Gaba(A Receptor Subunit Epsilon antibodyAnti-Gabaar Subunit Epsilon antibodyAnti-GABRE antibody |
Information sourced from Uniprot.org