Anti-GABRD antibody (N-Term) (STJA0003649)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein from the N-terminus of the delta subunit.
General Information
| Short Description | Rabbit polyclonal anti-GABAA Receptor d (N-Term) for use in WB, IHC and ICC in Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ICC |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000IHC 1:100ICC 1:500** |
| Formulation | 100 ยตl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 ยตg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Gabrd |
| Gene ID | 29689 |
| Uniprot ID | GBRD_RAT |
| Immunogen | Fusion protein from the N-terminus of the delta subunit. |
| Immunogen Region | N-Term |
Additional Info
| Tissue Specificity | Found in the brain, in cerebellar granule cells. Expressed in lungs, in alveolar epithelium. |
| Function | Delta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing delta/GABRD subunits are predominantly expressed and located in extrasynaptic or perisynaptic positions on hippocampus and cerebellar granule cells, and contribute to the tonic GABAergic inhibition. GABAAR containing alpha-4-beta-3-delta subunits can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit DeltaGaba(A Receptor Subunit DeltaGabaar Subunit Delta |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinDelta Subunits Are Found Only On The Extrasynaptic Somatic And Dendritic Membranes |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Delta antibodyAnti-Gaba(A Receptor Subunit Delta antibodyAnti-Gabaar Subunit Delta antibodyAnti-Gabrd antibody |
Information sourced from Uniprot.org