| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse/Rat/Bovine/Canine/Human/Non-Human Primates |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GABAA Receptor b2 (Cytoplasmic Loop) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Purification: |
This antibody was antigen affinity purified from serum. |
| Dilution Range: |
WB 1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Gabrb2 |
| Gene ID: |
25451 |
| Uniprot ID: |
GBRB2_RAT |
| Immunogen Region: |
Cytoplasmic Loop |
| Immunogen: |
Fusion protein from the cytoplasmic loop of the beta 2 subunit. |
| Tissue Specificity | Expressed in brain (at protein level), in cerebellar granule cells. Expressed in lungs, in alveolar epithelium. |
| Post Translational Modifications | Glycosylated. |
| Function | Beta subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. GABAARs containing alpha-1 and beta-2 or -3 subunits exhibit synaptogenic activity.the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. Extrasynaptic beta-2 receptors contribute to the tonic GABAergic inhibition. Beta-containing GABAARs can simultaneously bind GABA and histamine where histamine binds at the interface of two neighboring beta subunits, which may be involved in the regulation of sleep and wakefulness. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Beta-2Gaba(A Receptor Subunit Beta-2Gabaar Subunit Beta-2 |
| Database Links | Reactome: R-RNO-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneThe Beta-2 Subunits Are Present In Golgi Synapses And On The Extrasynaptic Membranes (Alpha-1/6-Beta-2/3-Gamma-2 Receptors)And In Some Of The Mossy Fiber To Granule Cell Synapses (Alpha-6-Beta-2/3-Gamma-2 Receptors)Present In Gabaergic And Glutamatergic Synapses On Granule CellsThe Beta-2 Subunit (Alpha-6-Beta-2/3-Delta Receptors) Are Found Only On The Extrasynaptic Somatic And Dendritic Membranes |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-2 antibodyAnti-Gaba(A Receptor Subunit Beta-2 antibodyAnti-Gabaar Subunit Beta-2 antibodyAnti-Gabrb2 antibodyAnti-Gabrb-2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
