Anti-GABRA2 antibody (Cytoplasmic Loop) (STJA0003641)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein from the cytoplasmic loop of the alpha 2 subunit.
General Information
| Short Description | Rabbit polyclonal anti-GABA A Receptor a 2 (Cytoplasmic Loop) for use in WB and ICC in Mouse, Bovine, Canine, Human, Non-Human Primates, Rat and Zebrafish samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC |
| Host | Rabbit |
| Reactivity | Mouse/Bovine/Canine/Human/Non-Human Primates/Rat/Zebrafish |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | This antibody was antigen affinity purified from pooled serum. |
| Dilution Range | WB 1:1000ICC 1:1000 |
| Formulation | 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Gabra2Uniprot ID=GBRA2_RAT" |
| Immunogen | Fusion protein from the cytoplasmic loop of the alpha 2 subunit. |
| Immunogen Region | Cytoplasmic Loop |
Additional Info
| Tissue Specificity | Expressed in brain (at protein level). |
| Post Translational Modifications | Glycosylated. |
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-2Gaba(A Receptor Subunit Alpha-2Gabaar Subunit Alpha-2 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle MembraneCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 antibodyAnti-Gaba(A Receptor Subunit Alpha-2 antibodyAnti-Gabaar Subunit Alpha-2 antibodyAnti-Gabra2 antibodyAnti-Gabra-2 antibody |
Information sourced from Uniprot.org