• Western blot with Anti-GABRB2 Antibody (STJ501119) with peptide on at 1:500 dilution in buffer.

Anti-GABRB2 antibody (350-400) (STJ501119)

SKU:
STJ501119

Current Stock:
Host: Rabbit
Applications: ELISA, IP, WB
Reactivity: Cat, Human
Note: FOR RESEARCH USE ONLY (RUO).
Short Description: Rabbit polyclonal antibody anti-GABRB2 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GABRB2
Gene ID: 2561
Uniprot ID: GBRB2_HUMAN
Immunogen Region: 350-400
Immunogen: Synthetic peptide taken within amino acid region 350-400 on human gamma-aminobutyric acid receptor subunit beta-2 protein.
Tissue Specificity Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Post Translational Modifications Glycosylated.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Beta-2
Gaba(A Receptor Subunit Beta-2
Database Links Reactome: R-HSA-1236394
Reactome: R-HSA-977443
Cellular Localisation Cell Junction
Synapse
Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-2 antibody
Anti-Gaba(A Receptor Subunit Beta-2 antibody
Anti-GABRB2 antibody

Information sourced from Uniprot.org

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