||ELISA, IP, WB
||FOR RESEARCH USE ONLY (RUO).
||Rabbit polyclonal antibody anti-GABRB2 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
||WB: 1:500DB: 1:10, 000ELISA: 1:10, 000IP: 1:150
||Store at-20°C for long term storage. Avoid freeze-thaw cycles.
||Synthetic peptide taken within amino acid region 350-400 on human gamma-aminobutyric acid receptor subunit beta-2 protein.
| Tissue Specificity || Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression. |
| Post Translational Modifications || Glycosylated. |
| Function || Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine. |
| Protein Name || Gamma-Aminobutyric Acid Receptor Subunit Beta-2Gaba(A Receptor Subunit Beta-2 |
| Database Links || Reactome: R-HSA-1236394Reactome: R-HSA-977443 |
| Cellular Localisation || Cell JunctionSynapsePostsynaptic Cell MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmic Vesicle Membrane |
| Alternative Antibody Names || Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-2 antibodyAnti-Gaba(A Receptor Subunit Beta-2 antibodyAnti-GABRB2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance