• Immunohistochemistry with Anti-GABRB2 Antibody (STJ501118) at 1:100 dilution in Buffer. DAB (brown) staining and Haematoxylin QS (blue) counterstain. 40X magnification on Leica DM4000. FFPE section.

Anti-GABRB2 antibody (1-50) (STJ501118)

SKU:
STJ501118-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABRB2 (1-50) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.55-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:150
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: GABRB2
Gene ID: 2561
Uniprot ID: GBRB2_HUMAN
Immunogen Region: 1-50
Specificity: Will label various GABA B subunit 2 variants.
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human gamma-aminobutyric acid A receptor beta 2 protein.
Tissue Specificity Isoform 1 and isoform 2 show reduced expression in schizophrenic brain. Isoform 3 shows increased expression in schizophrenic and bipolar disorder brains while isoform 4 shows reduced expression.
Post Translational Modifications Glycosylated.
Function Ligand-gated chloride channel which is a component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the brain. Plays an important role in the formation of functional inhibitory GABAergic synapses in addition to mediating synaptic inhibition as a GABA-gated ion channel. The gamma2 subunit is necessary but not sufficient for a rapid formation of active synaptic contacts and the synaptogenic effect of this subunit is influenced by the type of alpha and beta subunits present in the receptor pentamer. The alpha1/beta2/gamma2 receptor and the alpha2/beta2/gamma2 receptor exhibit synaptogenic activity. Functions also as histamine receptor and mediates cellular responses to histamine.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Beta-2
Gaba(A Receptor Subunit Beta-2
Database Links Reactome: R-HSA-1236394
Reactome: R-HSA-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasmic Vesicle Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Beta-2 antibody
Anti-Gaba(A Receptor Subunit Beta-2 antibody
Anti-GABRB2 antibody

Information sourced from Uniprot.org

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