• Western blot of mouse forebrain lysates from Wild Type (WT) and Alpha 6-knockout (K/O) animals showing specific immunolabeling of the ~57 kDa Alpha 6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha 6-knockout animals.

Anti-GABRA6 antibody (Cytoplasmic Loop) (STJA0003644)

SKU:
STJA0003644-100

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Host: Rabbit
Applications: WB
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GABAA Receptor a 6 (Cytoplasmic Loop) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 100 µl in 10 mM HEPES (pH 7.5) , 150 mM NaCl, 100 µg per ml BSA and 50% Glycerol.
Purification: This antibody was antigen affinity purified from serum.
Dilution Range: WB 1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Gabra6
Gene ID: 29708
Uniprot ID: GBRA6_RAT
Immunogen Region: Cytoplasmic Loop
Immunogen: Fusion protein from the cytoplasmic loop of the alpha 6 subunit.
Tissue Specificity Expressed in brain, in cerebellar granule cells.
Function Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Alpha-6/GABRA6 subunits are found at both synaptic and extrasynaptic sites. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. Extrasynaptic alpha-6-containing receptors contribute to the tonic GABAergic inhibition. Alpha-6 subunits are also present on glutamatergic synapses.
Protein Name Gamma-Aminobutyric Acid Receptor Subunit Alpha-6
Gaba(A Receptor Subunit Alpha-6
Gabaar Subunit Alpha-6
Database Links Reactome: R-RNO-977443
Cellular Localisation Postsynaptic Cell Membrane
Multi-Pass Membrane Protein
Cell Membrane
Present In Golgi Synapses
On The Extrasynaptic Membranes
And In Some Of The Mossy Fiber To Granule Cell Synapses
Also Found On The Extrasynaptic Somatic And Dendritic Membranes
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-6 antibody
Anti-Gaba(A Receptor Subunit Alpha-6 antibody
Anti-Gabaar Subunit Alpha-6 antibody
Anti-Gabra6 antibody
Anti-Gabra-6 antibody

Information sourced from Uniprot.org

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