Anti-GABRA5 antibody (32-259) (STJ115919)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GABRA5 (32-259) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GABRA5 |
| Gene ID | 2558 |
| Uniprot ID | GBRA5_HUMAN |
| Immunogen Region | 32-259 |
| Immunogen Sequence | QMPTSSVKDETNDNITIFTR ILDGLLDGYDNRLRPGLGER ITQVRTDIYVTSFGPVSDTE MEYTIDVFFRQSWKDERLRF KGPMQRLPLNNLLASKIWTP DTFFHNGKKSIAHNMTTPNK LLRLEDDGTLLYTMRLTISA ECPMQLEDFPMDAHACPLKF GSYAYPNSEVVYVWTNGSTK SVVVAEDGSRLNQYHLMGQT VGTENISTSTGEYTIMTAHF HLKRKIGY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 32-259 of human GABRA5 (NP_000801.1). |
Additional Info
| Function | Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interface(s). When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. GABAARs containing alpha-5/GABRA5 subunits are mainly extrasynaptic and contribute to the tonic GABAergic inhibition in the hippocampus. Extrasynaptic alpha-5-containing GABAARs in CA1 pyramidal neurons play a role in learning and memory processes. |
| Protein Name | Gamma-Aminobutyric Acid Receptor Subunit Alpha-5Gaba(A Receptor Subunit Alpha-5Gabaar Subunit Alpha-5 |
| Database Links | Reactome: R-HSA-977443 |
| Cellular Localisation | Postsynaptic Cell MembraneMulti-Pass Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-5 antibodyAnti-Gaba(A Receptor Subunit Alpha-5 antibodyAnti-Gabaar Subunit Alpha-5 antibodyAnti-GABRA5 antibody |
Information sourced from Uniprot.org