Anti-GABRA2 antibody (300-400) (STJ23729)

Name: Anti-GABRA2 antibody (300-400) (STJ23729)
SKU: STJ23729
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ23729

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Short Description	Rabbit polyclonal GABRA2 (300-400) antibody for use in WB, IHC-P and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/IHC-P/ELISA
Host	Rabbit
Reactivity	Human/Mouse
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 IHC-P:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	GABRA2
Gene ID	2555
Uniprot ID	GBRA2_HUMAN
Immunogen Region	300-400
Immunogen Sequence	ARNSLPKVAYATAMDWFIAV CYAFVFSALIEFATVNYFTK RGWAWDGKSVVNDKKKEKAS VMIQNNAYAVAVANYAPNLS KDPVLSTISKSATTPEPNKK P
Specificity	A synthetic peptide corresponding to a sequence within amino acids 300-400 of human GABRA2 (NP_000798.2).

Post Translational Modifications	Glycosylated.
Function	Alpha subunit of the heteropentameric ligand-gated chloride channel gated by gamma-aminobutyric acid (GABA), a major inhibitory neurotransmitter in the brain. GABA-gated chloride channels, also named GABA(A) receptors (GABAAR), consist of five subunits arranged around a central pore and contain GABA active binding site(s) located at the alpha and beta subunit interfaces. When activated by GABA, GABAARs selectively allow the flow of chloride anions across the cell membrane down their electrochemical gradient. Chloride influx into the postsynaptic neuron following GABAAR opening decreases the neuron ability to generate a new action potential, thereby reducing nerve transmission. The alpha-2 subunit exhibits synaptogenic activity together with beta-2 and very little to no activity together with beta-3, the gamma-2 subunit being necessary but not sufficient to induce rapid synaptic contacts formation.
Protein Name	Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 Gaba(A Receptor Subunit Alpha-2 Gabaar Subunit Alpha-2
Database Links	Reactome: R-HSA-977443
Cellular Localisation	Postsynaptic Cell Membrane Multi-Pass Membrane Protein Cell Membrane Cytoplasmic Vesicle Membrane Cell Projection Dendrite
Alternative Antibody Names	Anti-Gamma-Aminobutyric Acid Receptor Subunit Alpha-2 antibody Anti-Gaba(A Receptor Subunit Alpha-2 antibody Anti-Gabaar Subunit Alpha-2 antibody Anti-GABRA2 antibody

Information sourced from Uniprot.org