Anti-GABBR2 antibody (830-910 aa) (STJ96379)

SKU:
STJ96379

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Gamma-aminobutyric acid type B receptor subunit 2 (830-910 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GABBR2
Gene ID: 9568
Uniprot ID: GABR2_HUMAN
Immunogen Region: 830-910 aa
Specificity: GABAB R2 Polyclonal Antibody detects endogenous levels of GABAB R2 protein.
Immunogen: Synthesized peptide derived from GABAB R2 at the amino acid range 830-910
Function Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
Protein Name Gamma-Aminobutyric Acid Type B Receptor Subunit 2
Gaba-B Receptor 2
Gaba-B-R2
Gaba-Br2
Gababr2
Gb2
G-Protein Coupled Receptor 51
Hg20
Database Links Reactome: R-HSA-1296041
Reactome: R-HSA-418594
Reactome: R-HSA-420499
Reactome: R-HSA-977444
Reactome: R-HSA-997272
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Coexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma Membrane
In Contrast
Gabbr2 Does Not Depend On Gabbr1 For Transport To The Cell Membrane
Alternative Antibody Names Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 2 antibody
Anti-Gaba-B Receptor 2 antibody
Anti-Gaba-B-R2 antibody
Anti-Gaba-Br2 antibody
Anti-Gababr2 antibody
Anti-Gb2 antibody
Anti-G-Protein Coupled Receptor 51 antibody
Anti-Hg20 antibody
Anti-GABBR2 antibody
Anti-GPR51 antibody
Anti-GPRC3B antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance