Anti-GABBR1 antibody (N-Term) (STJ13101173)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from n-terminal (Extracellular domain) region of mouse GABA B Receptor 1 (GABBR1) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-GABBR1 (N-Term) for use in IHC and WB in Mouse, Rat and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Mouse/Rat/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | Gabbr1 |
| Gene ID | 54393 |
| Uniprot ID | GABR1_MOUSE |
| Immunogen | A synthetic peptide from n-terminal (Extracellular domain) region of mouse GABA B Receptor 1 (GABBR1) conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | N-Term |
| Specificity | Specific for GABBR1. |
Additional Info
| Function | Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2. Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipid hydrolysis. Calcium is required for high affinity binding to GABA. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception. |
| Protein Name | Gamma-Aminobutyric Acid Type B Receptor Subunit 1Gaba-B Receptor 1Gaba-B-R1Gaba-Br1Gababr1Gb1 |
| Database Links | Reactome: R-MMU-1296041Reactome: -MMU-418594Reactome: -MMU-420499Reactome: -MMU-977444Reactome: -MMU-997272 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteCoexpression Of Gabbr1 And Gabbr2 Is Required For Gabbr1 Maturation And Transport To The Plasma MembraneColocalizes With Atf4 In Hippocampal Neuron Dendritic Membranes |
| Alternative Antibody Names | Anti-Gamma-Aminobutyric Acid Type B Receptor Subunit 1 antibodyAnti-Gaba-B Receptor 1 antibodyAnti-Gaba-B-R1 antibodyAnti-Gaba-Br1 antibodyAnti-Gababr1 antibodyAnti-Gb1 antibodyAnti-Gabbr1 antibody |
Information sourced from Uniprot.org