Anti-GAB2 antibody (589-638 aa) (STJ93180)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human Gab2 at the amino acid range 589-638
General Information
| Short Description | Rabbit polyclonal anti-GRB2-associated-binding protein 2 (589-638 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GAB2 |
| Gene ID | 9846 |
| Uniprot ID | GAB2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human Gab2 at the amino acid range 589-638 |
| Immunogen Region | 589-638 aa |
| Specificity | Gab 2 Polyclonal Antibody detects endogenous levels of Gab 2 protein. |
Additional Info
| Function | Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis. |
| Protein Name | Grb2-Associated-Binding Protein 2Grb2-Associated Binder 2Growth Factor Receptor Bound Protein 2-Associated Protein 2Pp100 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1257604Reactome: R-HSA-1433557Reactome: R-HSA-1839117Reactome: R-HSA-2219530Reactome: R-HSA-2730905Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-8983432Reactome: R-HSA-912526Reactome: R-HSA-9607240Reactome: R-HSA-9645135Reactome: R-HSA-9674555Reactome: R-HSA-9680350Reactome: R-HSA-9702518Reactome: R-HSA-9703465Reactome: R-HSA-9703648 |
| Cellular Localisation | CytoplasmCell MembraneMembrane Raft |
| Alternative Antibody Names | Anti-Grb2-Associated-Binding Protein 2 antibodyAnti-Grb2-Associated Binder 2 antibodyAnti-Growth Factor Receptor Bound Protein 2-Associated Protein 2 antibodyAnti-Pp100 antibodyAnti-GAB2 antibodyAnti-KIAA0571 antibody |
Information sourced from Uniprot.org