Anti-G3BP2 antibody (140-280) (STJ27822)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal G3BP2 (140-280) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | G3BP2 |
| Gene ID | 9908 |
| Uniprot ID | G3BP2_HUMAN |
| Immunogen Region | 140-280 |
| Immunogen Sequence | DSEPELDEESEDEVEEEQEE RQPSPEPVQENANSGYYEAH PVTNGIEEPLEESSHEPEPE PESETKTEELKPQVEEKNLE ELEEKSTTPPPAEPVSLPQE PPKPRVEAKPEVQSQPPRVR EQRPRERPGFPPRGPRPGRG D |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 140-280 of human G3BP2 (NP_987100.1). |
Additional Info
| Post Translational Modifications | (Microbial infection) Cleaved by foot-and-mouth disease virus leader protease.this cleavage suppresses the formation of cytoplasmic stress granules. |
| Function | Scaffold protein that plays an essential role in cytoplasmic stress granule formation which acts as a platform for antiviral signaling. Plays an essential role in stress granule formation. Stress granules are membraneless compartments that store mRNAs and proteins, such as stalled translation pre-initiation complexes, in response to stress. Promotes formation of stress granules phase-separated membraneless compartment by undergoing liquid-liquid phase separation (LLPS) upon unfolded RNA-binding: functions as a molecular switch that triggers RNA-dependent LLPS in response to a rise in intracellular free RNA concentrations. |
| Protein Name | Ras Gtpase-Activating Protein-Binding Protein 2G3bp-2Gap Sh3 Domain-Binding Protein 2 |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmStress Granule |
| Alternative Antibody Names | Anti-Ras Gtpase-Activating Protein-Binding Protein 2 antibodyAnti-G3bp-2 antibodyAnti-Gap Sh3 Domain-Binding Protein 2 antibodyAnti-G3BP2 antibodyAnti-KIAA0660 antibody |
Information sourced from Uniprot.org