Anti-FYB antibody [R04-2T9] (STJA0037030)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human FYB
General Information
| Short Description | Rabbit monoclonal anti-FYB for use in WB, IHC-P, ICC and IF in Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Mouse/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R04-2T9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FYB1 |
| Gene ID | 2533 |
| Uniprot ID | FYB1_HUMAN |
| Immunogen | A synthesized peptide derived from human FYB |
Additional Info
| Tissue Specificity | Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. |
| Post Translational Modifications | T-cell receptor ligation leads to increased tyrosine phosphorylation. |
| Function | Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. Modulates the expression of IL2. Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. |
| Protein Name | Fyn-Binding Protein 1Adhesion And Degranulation Promoting Adaptor ProteinAdapFyb-120/130P120/P130Fyn-T-Binding ProteinSlap-130Slp-76-Associated Phosphoprotein |
| Database Links | Reactome: R-HSA-202433Reactome: R-HSA-391160 |
| Cellular Localisation | CytoplasmNucleusCell JunctionColocalizes With Tmem47 At Cell-Cell Contacts In Podocytes |
| Alternative Antibody Names | Anti-Fyn-Binding Protein 1 antibodyAnti-Adhesion And Degranulation Promoting Adaptor Protein antibodyAnti-Adap antibodyAnti-Fyb-120/130 antibodyAnti-P120/P130 antibodyAnti-Fyn-T-Binding Protein antibodyAnti-Slap-130 antibodyAnti-Slp-76-Associated Phosphoprotein antibodyAnti-FYB1 antibodyAnti-FYB antibodyAnti-SLAP130 antibody |
Information sourced from Uniprot.org