Anti-FXR2 antibody (551-600 aa) (STJ93168)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FXR2 at the amino acid range 551-600
General Information
| Short Description | Rabbit polyclonal anti-RNA-binding protein FXR2 (551-600 aa) for use in WB, IHC, IF and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FXR2 |
| Gene ID | 9513 |
| Uniprot ID | FXR2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FXR2 at the amino acid range 551-600 |
| Immunogen Region | 551-600 aa |
| Specificity | FXR2 Polyclonal Antibody detects endogenous levels of FXR2 protein. |
Additional Info
| Function | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability. Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus. |
| Protein Name | Rna-Binding Protein Fxr2Fxr2pFmr1 Autosomal Homolog 2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranulePostsynapseSpecifically Localizes To Cytoplasmic Ribonucleoprotein Membraneless CompartmentsLocalization To The Post-Synaptic Region Is Dependent On Fmr1 |
| Alternative Antibody Names | Anti-Rna-Binding Protein Fxr2 antibodyAnti-Fxr2p antibodyAnti-Fmr1 Autosomal Homolog 2 antibodyAnti-FXR2 antibodyAnti-FMR1L2 antibody |
Information sourced from Uniprot.org