| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FXR2 (550-650) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FXR2 |
| Gene ID: |
9513 |
| Uniprot ID: |
FXR2_HUMAN |
| Immunogen Region: |
550-650 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 550-650 of human FXR2 (NP_004851.2). |
| Immunogen Sequence: |
RRRTDEDRTVMDGGLESDGP NMTENGLEDESRPQRRNRSR RRRNRGNRTDGSISGDRQPV TVADYISRAESQSRQRPPLE RTKPSEDSLSGQKGDSVSKL P |
| Tissue Specificity | Expressed in all tissues examined including heart, brain, kidney and testis. In brain, present at high level in neurons and especially in the Purkinje cells at the interface between the granular layer and the molecular layer (at protein level). |
| Function | mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for adult hippocampal neurogenesis. Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs. Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs: mRNAs storage into membraneless compartments regulates their translation and/or stability. Acts as a regulator of adult hippocampal neurogenesis by regulating translation and/or stability of NOG mRNA, thereby preventing NOG protein expression in the dentate gyrus. |
| Protein Name | Rna-Binding Protein Fxr2Fxr2pFmr1 Autosomal Homolog 2 |
| Cellular Localisation | CytoplasmCytoplasmic Ribonucleoprotein GranulePostsynapseSpecifically Localizes To Cytoplasmic Ribonucleoprotein Membraneless CompartmentsLocalization To The Post-Synaptic Region Is Dependent On Fmr1 |
| Alternative Antibody Names | Anti-Rna-Binding Protein Fxr2 antibodyAnti-Fxr2p antibodyAnti-Fmr1 Autosomal Homolog 2 antibodyAnti-FXR2 antibodyAnti-FMR1L2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
