Anti-FUT6 antibody (STJA0007832)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FUT6
General Information
| Short Description | Rabbit polyclonal anti-4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT6 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FUT6 |
| Gene ID | 2528 |
| Uniprot ID | FUT6_HUMAN |
| Immunogen | Synthesized peptide derived from human FUT6 |
| Specificity | This antibody detects endogenous levels of FUT6 at Human |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage releases a secreted glycoform of 43 kDa. |
| Function | Isoform 1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates. Isoform 2: Does not have alpha(1,3)-fucosyltransferase activity. |
| Protein Name | 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6Fucosyltransferase 6Fucosyltransferase ViFuc-TviFuct-ViGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6 antibodyAnti-Fucosyltransferase 6 antibodyAnti-Fucosyltransferase Vi antibodyAnti-Fuc-Tvi antibodyAnti-Fuct-Vi antibodyAnti-Galactoside 3-L-Fucosyltransferase antibodyAnti-FUT6 antibodyAnti-FCT3A antibody |
Information sourced from Uniprot.org