| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FUT6 (170-359) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FUT6 |
| Gene ID: |
2528 |
| Uniprot ID: |
FUT6_HUMAN |
| Immunogen Region: |
170-359 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 170-359 of human FUT6 (NP_000141.1). |
| Immunogen Sequence: |
WLEPWSGQPAHPPLNLSAKT ELVAWAVSNWGPNSARVRYY QSLQAHLKVDVYGRSHKPLP QGTMMETLSRYKFYLAFENS LHPDYITEKLWRNALEAWAV PVVLGPSRSNYERFLPPDAF IHVDDFQSPKDLARYLQELD KDHARYLSYFRWRETLRPRS FSWALAFCKACWKLQEESRY QTRGIAAWFT |
| Tissue Specificity | Kidney, liver, colon, small intestine, bladder, uterus and salivary gland. |
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage releases a secreted glycoform of 43 kDa. |
| Function | Isoform 1: Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the N-acetyl glucosamine (GlcNAc) of a distal alpha2,3 sialylated lactosamine unit of a glycoprotein- or a glycolipid-linked sialopolylactosamines chain or of a distal or internal lactosamine unit of a neutral glycoprotein- or a glycolipid-linked polylactosamines chain through an alpha-1,3 glycosidic linkage and participates in surface expression of the sialyl Lewis X (sLe(x)), Lewis X (Le(x)) and non sialylated VIM2 determinants. Moreover transfers fucose to H-type 2 (Fucalpha1-2Galbeta1-4GlcNAc) chain acceptor substrates and participates in difucosylated sialyl Lewis x determinants. Also fucosylates a polylactosamine substrate having a 6 sulfate modification at the GlcNAc moiety and gives rise to sialyl and non-sialyl 6-sulfo lewis X. Does not have activity towards type 1 ((Galbeta1-3GlcNAc)) and H-type 1 chain (Fucalpha1-2Galbeta1-3GlcNAc) acceptors substrates. Isoform 2: Does not have alpha(1,3)-fucosyltransferase activity. |
| Protein Name | 4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6Fucosyltransferase 6Fucosyltransferase ViFuc-TviFuct-ViGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinSecretedMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase Fut6 antibodyAnti-Fucosyltransferase 6 antibodyAnti-Fucosyltransferase Vi antibodyAnti-Fuc-Tvi antibodyAnti-Fuct-Vi antibodyAnti-Galactoside 3-L-Fucosyltransferase antibodyAnti-FUT6 antibodyAnti-FCT3A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
