Anti-FUT4 antibody (22-71 aa) (STJ92091)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human FucT-IV at the amino acid range 22-71
General Information
| Short Description | Rabbit polyclonal anti-Alpha-1, 3-fucosyltransferase 4 (22-71 aa) for use in IHC, IF, IHC and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC 1:100-1:300ELISA 1:40000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FUT4 |
| Gene ID | 2526 |
| Uniprot ID | FUT4_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human FucT-IV at the amino acid range 22-71 |
| Immunogen Region | 22-71 aa |
| Specificity | CD15 Polyclonal Antibody detects endogenous levels of CD15 protein. |
Additional Info
| Function | Isoform Short: Catalyzes alpha(1->3) linkage of fucosyl moiety transferred from GDP-beta-L-fucose to N-acetyl glucosamine (GlcNAc) within type 2 lactosamine (LacNAc, Gal-beta(1->4)GlcNAc) glycan attached to N- or O-linked glycoproteins. Robustly fucosylates nonsialylated distal LacNAc unit of the polylactosamine chain to form Lewis X antigen (CD15), a glycan determinant known to mediate important cellular functions in development and immunity. Fucosylates with lower efficiency sialylated LacNAc acceptors to form sialyl Lewis X and 6-sulfo sialyl Lewis X determinants that serve as recognition epitopes for C-type lectins. Together with FUT7 contributes to SELE, SELL and SELP selectin ligand biosynthesis and selectin-dependent lymphocyte homing, leukocyte migration and blood leukocyte homeostasis. In a cell type specific manner, may also fucosylate the internal LacNAc unit of the polylactosamine chain to form VIM-2 antigen that serves as recognition epitope for SELE. Isoform Long: Does not generate Lewis X antigens. |
| Protein Name | Alpha-(1 -3-Fucosyltransferase 44-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-FucosyltransferaseElam-1 Ligand FucosyltransferaseFucosyltransferase 4Fucosyltransferase IvFuc-TivFuct-IvGalactoside 3-L-Fucosyltransferase |
| Database Links | Reactome: R-HSA-9037629 |
| Cellular Localisation | Golgi ApparatusGolgi Stack MembraneSingle-Pass Type Ii Membrane ProteinMembrane-Bound Form In Trans Cisternae Of Golgi |
| Alternative Antibody Names | Anti-Alpha-(1 -3-Fucosyltransferase 4 antibodyAnti-4-Galactosyl-N-Acetylglucosaminide 3-Alpha-L-Fucosyltransferase antibodyAnti-Elam-1 Ligand Fucosyltransferase antibodyAnti-Fucosyltransferase 4 antibodyAnti-Fucosyltransferase Iv antibodyAnti-Fuc-Tiv antibodyAnti-Fuct-Iv antibodyAnti-Galactoside 3-L-Fucosyltransferase antibodyAnti-FUT4 antibodyAnti-ELFT antibodyAnti-FCT3A antibody |
Information sourced from Uniprot.org