Anti-FUS antibody (STJA0006732)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FUS/TLS
General Information
| Short Description | Rabbit polyclonal anti-RNA-binding protein FUS for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FUS |
| Gene ID | 2521 |
| Uniprot ID | FUS_HUMAN |
| Immunogen | Synthesized peptide derived from human FUS/TLS |
| Specificity | This antibody detects endogenous levels of FUS/TLS at Human, Mouse |
Additional Info
| Post Translational Modifications | Arg-216 and Arg-218 are dimethylated, probably to asymmetric dimethylarginine. Phosphorylated in its N-terminal serine residues upon induced DNA damage. ATM and DNA-PK are able to phosphorylate FUS N-terminal region. |
| Function | DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to ssRNA containing the consensus sequence 5'-AGGUAA-3'. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Also binds its own pre-mRNA and autoregulates its expression.this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis. |
| Protein Name | Rna-Binding Protein Fus75 Kda Dna-Pairing ProteinOncogene FusOncogene TlsPomp75Translocated In Liposarcoma Protein |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203 |
| Cellular Localisation | NucleusDisplays A Punctate Pattern Inside The Nucleus And Is Excluded From Nucleoli |
| Alternative Antibody Names | Anti-Rna-Binding Protein Fus antibodyAnti-75 Kda Dna-Pairing Protein antibodyAnti-Oncogene Fus antibodyAnti-Oncogene Tls antibodyAnti-Pomp75 antibodyAnti-Translocated In Liposarcoma Protein antibodyAnti-FUS antibodyAnti-TLS antibody |
Information sourced from Uniprot.org