Anti-FTSJ3 antibody (628-678) (STJA0006556)

SKU:
STJA0006556

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-pre-rRNA 2 O-ribose RNA methyltransferase FTSJ3 (628-678) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FTSJ3
Gene ID: 117246
Uniprot ID: SPB1_HUMAN
Immunogen Region: 628-678
Specificity: This antibody detects endogenous levels of human RRMJ3
Immunogen: Synthesized peptide derived from human RRMJ3 AA range: 628-678
Function RNA 2'-O-methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation. (Microbial infection) In case of infection by HIV-1 virus, recruited to HIV-1 RNA and catalyzes 2'-O-methylation of the viral genome, allowing HIV-1 virus to escape the innate immune system. RNA 2'-O-methylation provides a molecular signature for discrimination of self from non-self and is used by HIV-1 to evade innate immune recognition by IFIH1/MDA5. Mediates methylation of internal residues of HIV-1 RNA, with a strong preference for adenosine. Recruited to HIV-1 RNA via interaction with TARBP2/TRBP.
Protein Name Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3
Protein Ftsj Homolog 3
Putative Rrna Methyltransferase 3
Database Links Reactome: R-HSA-6791226
Cellular Localisation Nucleus
Nucleolus
Alternative Antibody Names Anti-Pre-Rrna 2'-O-Ribose Rna Methyltransferase Ftsj3 antibody
Anti-Protein Ftsj Homolog 3 antibody
Anti-Putative Rrna Methyltransferase 3 antibody
Anti-FTSJ3 antibody
Anti-SB92 antibody

Information sourced from Uniprot.org

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