Anti-FTL antibody (1-175) (STJ26177)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FTL (1-175) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FTL |
| Gene ID | 2512 |
| Uniprot ID | FRIL_HUMAN |
| Immunogen Region | 1-175 |
| Immunogen Sequence | MSSQIRQNYSTDVEAAVNSL VNLYLQASYTYLSLGFYFDR DDVALEGVSHFFRELAEEKR EGYERLLKMQNQRGGRALFQ DIKKPAEDEWGKTPDAMKAA MALEKKLNQALLDLHALGSA RTDPHLCDFLETHFLDEEVK LIKKMGDHLTNLHRLGGPEA GLGEYLFERLTLKHD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-175 of human Ferritin Light Chain (NP_000137.2). |
Additional Info
| Function | Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney. Delivery to lysosomes by the cargo receptor NCOA4 for autophagic degradation and release or iron. |
| Protein Name | Ferritin Light ChainFerritin L Subunit |
| Database Links | Reactome: R-HSA-3000480Reactome: R-HSA-432722Reactome: R-HSA-6798695Reactome: R-HSA-917937 |
| Cellular Localisation | Cytoplasmic VesicleAutophagosomeCytoplasmAutolysosome |
| Alternative Antibody Names | Anti-Ferritin Light Chain antibodyAnti-Ferritin L Subunit antibodyAnti-FTL antibody |
Information sourced from Uniprot.org