• STJ73094 (0. 1µg/ml) staining of 3T3-L1 lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-FRS2 antibody (Internal) (STJ73094)

SKU:
STJ73094-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-FRS2 (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.1-0.3µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: FRS2
Gene ID: 10818
Uniprot ID: FRS2_HUMAN
Immunogen Region: Internal
Accession Number: NP_006645.3
Specificity: Reported variants represent identical protein: NP_001265284.1, NP_001265286.1, NP_001265283.1, NP_001265285.1, NP_001265282.1, NP_006645.3, NP_001036020.1, NP_001265280.1
Immunogen Sequence: SRDEDDNLGPKTPS
Post Translational Modifications Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by NGF or FGF2. Phosphorylated on tyrosine residues by activated ALK and FGFR1. Phosphorylated on tyrosine residues upon activation of FGFR2 and FGFR3. Phosphorylated on threonine residues by MAP kinases.this inhibits tyrosine phosphorylation, and thereby down-regulates FRS2-mediated activation of MAP kinases. Ubiquitinated when tyrosine phosphorylated and in a complex with GRB2. The unphosphorylated form is not subject to ubiquitination.
Function Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
Protein Name Fibroblast Growth Factor Receptor Substrate 2
Fgfr Substrate 2
Fgfr-Signaling Adaptor Snt
Suc1-Associated Neurotrophic Factor Target 1
Snt-1
Database Links Reactome: R-HSA-109704
Reactome: R-HSA-1257604
Reactome: R-HSA-170968
Reactome: R-HSA-201556
Reactome: R-HSA-2219530
Reactome: R-HSA-5654689
Reactome: R-HSA-5654693
Reactome: R-HSA-5654695
Reactome: R-HSA-5654700
Reactome: R-HSA-5654706
Reactome: R-HSA-5654710
Reactome: R-HSA-5654712
Reactome: R-HSA-5654720
Reactome: R-HSA-5654726
Reactome: R-HSA-5654727
Reactome: R-HSA-5654732
Reactome: R-HSA-5654733
Reactome: R-HSA-5655253
Reactome: R-HSA-5655291
Reactome: R-HSA-5655302
Reactome: R-HSA-5655332
Reactome: R-HSA-5673001
Reactome: R-HSA-6811558
Reactome: R-HSA-8853659
Reactome: R-HSA-9028731
Reactome: R-HSA-9696270
Reactome: R-HSA-9696273
Reactome: R-HSA-9725370
Cellular Localisation Endomembrane System
Cytoplasmic
Membrane-Bound
Alternative Antibody Names Anti-Fibroblast Growth Factor Receptor Substrate 2 antibody
Anti-Fgfr Substrate 2 antibody
Anti-Fgfr-Signaling Adaptor Snt antibody
Anti-Suc1-Associated Neurotrophic Factor Target 1 antibody
Anti-Snt-1 antibody
Anti-FRS2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance