Anti-FRK antibody (2-300 aa) [1A8H2C12] (STJ98353)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified recombinant fragment of Rak (aa2-300) expressed in E. Coli.
General Information
| Short Description | Mouse monoclonal anti-Tyrosine-protein kinase FRK (2-300 aa) for use in WB, IHC, IF and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1A8H2C12 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB 1:500-1:2000IHC 1:200-1:1000ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FRK |
| Gene ID | 2444 |
| Uniprot ID | FRK_HUMAN |
| Immunogen | Purified recombinant fragment of Rak (aa2-300) expressed in E. Coli. |
| Immunogen Region | 2-300 aa |
| Specificity | Rak Monoclonal Antibody detects endogenous levels of Rak protein. |
Additional Info
| Function | Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. |
| Protein Name | Tyrosine-Protein Kinase FrkFyn-Related KinaseNuclear Tyrosine Protein Kinase RakProtein-Tyrosine Kinase 5 |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmNucleusPredominantly Found In The NucleusWith A Small Fraction Found In The Cell Periphery |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Frk antibodyAnti-Fyn-Related Kinase antibodyAnti-Nuclear Tyrosine Protein Kinase Rak antibodyAnti-Protein-Tyrosine Kinase 5 antibodyAnti-FRK antibodyAnti-PTK5 antibodyAnti-RAK antibody |
Information sourced from Uniprot.org