Anti-FPR1 antibody (150-200) {Biotin} (STJ501083)

SKU:
STJ501083-100

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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human/Monkey/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FPR1 (150-200) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Biotin
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: FPR1
Gene ID: 2357
Uniprot ID: FPR1_HUMAN
Immunogen Region: 150-200
Immunogen: Synthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor.
Tissue Specificity Neutrophils.
Post Translational Modifications Phosphorylated.which is necessary for desensitization.
Function High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors. Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system. Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release. Receptor for cathepsin CTSG, leading to increased phagocyte chemotaxis.
Protein Name Fmet-Leu-Phe Receptor
Fmlp Receptor
N-Formyl Peptide Receptor
Fpr
N-Formylpeptide Chemoattractant Receptor
Database Links Reactome: R-HSA-418594
Reactome: R-HSA-444473
Reactome: R-HSA-6783783
Reactome: R-HSA-6798695
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalizes In Presence Of Its Ligands
Fmlp
Tafa4 And Ctsg
Alternative Antibody Names Anti-Fmet-Leu-Phe Receptor antibody
Anti-Fmlp Receptor antibody
Anti-N-Formyl Peptide Receptor antibody
Anti-Fpr antibody
Anti-N-Formylpeptide Chemoattractant Receptor antibody
Anti-FPR1 antibody

Information sourced from Uniprot.org

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