Anti-FPGS antibody [R06-6B1] (STJA0034329)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human FPGS
General Information
| Short Description | Rabbit monoclonal anti-FPGS for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-6B1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FPGS |
| Gene ID | 2356 |
| Uniprot ID | FOLC_HUMAN |
| Immunogen | A synthetic peptide of human FPGS |
Additional Info
| Function | Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates. |
| Protein Name | Folylpolyglutamate Synthase - MitochondrialFolylpoly-Gamma-Glutamate SynthetaseFpgsTetrahydrofolylpolyglutamate SynthaseTetrahydrofolate Synthase |
| Database Links | Reactome: R-HSA-196757 |
| Cellular Localisation | Isoform 1: Mitochondrion Inner MembraneMitochondrion MatrixIsoform 2: Cytoplasm |
| Alternative Antibody Names | Anti-Folylpolyglutamate Synthase - Mitochondrial antibodyAnti-Folylpoly-Gamma-Glutamate Synthetase antibodyAnti-Fpgs antibodyAnti-Tetrahydrofolylpolyglutamate Synthase antibodyAnti-Tetrahydrofolate Synthase antibodyAnti-FPGS antibody |
Information sourced from Uniprot.org