Anti-FOXA2 antibody [R07-3H4] (STJA0036321)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human FOXA2
General Information
| Short Description | Rabbit monoclonal anti-FOXA2 for use in WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-3H4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FOXA2 |
| Gene ID | 3170 |
| Uniprot ID | FOXA2_HUMAN |
| Immunogen | A synthesized peptide derived from human FOXA2 |
Additional Info
| Post Translational Modifications | Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation. |
| Function | Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-ACAATTAGTTGTAGCTTCT-3'. In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs.FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation. |
| Protein Name | Hepatocyte Nuclear Factor 3-BetaHnf-3-BetaHnf-3bForkhead Box Protein A2Transcription Factor 3bTcf-3b |
| Database Links | Reactome: R-HSA-210745Reactome: R-HSA-9796292Reactome: R-HSA-9823730Reactome: R-HSA-9925561 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Nucleus And Cytoplasm In A Crm1-Dependent MannerIn Response To Insulin Signaling Via Akt1 Is Exported From The Nucleus |
| Alternative Antibody Names | Anti-Hepatocyte Nuclear Factor 3-Beta antibodyAnti-Hnf-3-Beta antibodyAnti-Hnf-3b antibodyAnti-Forkhead Box Protein A2 antibodyAnti-Transcription Factor 3b antibodyAnti-Tcf-3b antibodyAnti-FOXA2 antibodyAnti-HNF3B antibodyAnti-TCF3B antibody |
Information sourced from Uniprot.org