Anti-FOLH1 antibody (100-200 aa) [ABT-PSMA] (STJ196863)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from the human Prostate-Specific Membrane Antigen (PSMA) at the amino acid range 100-200
General Information
| Short Description | Mouse monoclonal anti-Glutamate carboxypeptidase 2 (100-200 aa) for use in IHC and WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT-PSMA |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:100-500WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FOLH1 |
| Gene ID | 2346 |
| Uniprot ID | FOLH1_HUMAN |
| Immunogen | Synthesized peptide derived from the human Prostate-Specific Membrane Antigen (PSMA) at the amino acid range 100-200 |
| Immunogen Region | 100-200 aa |
| Specificity | This antibody detects endogenous levels of human Prostate-Specific Membrane Antigen (PSMA). Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair metho |
Additional Info
| Post Translational Modifications | The first two amino acids at the N-terminus of isoform PSMA' appear to be cleaved by limited proteolysis. The N-terminus is blocked. |
| Function | Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC. |
| Protein Name | Glutamate Carboxypeptidase 2Cell Growth-Inhibiting Gene 27 ProteinFolate Hydrolase 1Folylpoly-Gamma-Glutamate CarboxypeptidaseFgcpGlutamate Carboxypeptidase IiGcpiiMembrane Glutamate CarboxypeptidaseMgcpN-Acetylated-Alpha-Linked Acidic Dipeptidase INaaladase IProstate-Specific Membrane AntigenPsmPsmaPteroylpoly-Gamma-Glutamate Carboxypeptidase |
| Database Links | Reactome: R-HSA-8963693 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinIsoform Psma': Cytoplasm |
| Alternative Antibody Names | Anti-Glutamate Carboxypeptidase 2 antibodyAnti-Cell Growth-Inhibiting Gene 27 Protein antibodyAnti-Folate Hydrolase 1 antibodyAnti-Folylpoly-Gamma-Glutamate Carboxypeptidase antibodyAnti-Fgcp antibodyAnti-Glutamate Carboxypeptidase Ii antibodyAnti-Gcpii antibodyAnti-Membrane Glutamate Carboxypeptidase antibodyAnti-Mgcp antibodyAnti-N-Acetylated-Alpha-Linked Acidic Dipeptidase I antibodyAnti-Naaladase I antibodyAnti-Prostate-Specific Membrane Antigen antibodyAnti-Psm antibodyAnti-Psma antibodyAnti-Pteroylpoly-Gamma-Glutamate Carboxypeptidase antibodyAnti-FOLH1 antibodyAnti-FOLH antibodyAnti-NAALAD1 antibodyAnti-PSM antibodyAnti-PSMA antibodyAnti-GIG27 antibody |
Information sourced from Uniprot.org