Anti-Folate Binding Protein antibody [R02-3G2] (STJA0034323)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Folate Binding Protein
General Information
| Short Description | Rabbit monoclonal anti-Folate Binding Protein for use in WB and IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-3G2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FOLR1 |
| Gene ID | 2348 |
| Uniprot ID | FOLR1_HUMAN |
| Immunogen | A synthetic peptide of human Folate Binding Protein |
Additional Info
| Tissue Specificity | Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium. |
| Post Translational Modifications | The secreted form is derived from the membrane-bound form either by cleavage of the GPI anchor, or/and by proteolysis catalyzed by a metalloprotease. |
| Function | Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release. Required for normal embryonic development and normal cell proliferation. |
| Protein Name | Folate Receptor AlphaFr-AlphaAdult Folate-Binding ProteinFbpFolate Receptor 1Folate Receptor - AdultKb Cells FbpOvarian Tumor-Associated Antigen Mov18 |
| Database Links | Reactome: R-HSA-204005Reactome: R-HSA-5694530Reactome: R-HSA-6807878 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorApical Cell MembraneBasolateral Cell MembraneGpi-Like-AnchorSecretedCytoplasmic VesicleClathrin-Coated VesicleEndosomeEndocytosed Into Cytoplasmic Vesicles And Then Recycled To The Cell Membrane |
| Alternative Antibody Names | Anti-Folate Receptor Alpha antibodyAnti-Fr-Alpha antibodyAnti-Adult Folate-Binding Protein antibodyAnti-Fbp antibodyAnti-Folate Receptor 1 antibodyAnti-Folate Receptor - Adult antibodyAnti-Kb Cells Fbp antibodyAnti-Ovarian Tumor-Associated Antigen Mov18 antibodyAnti-FOLR1 antibodyAnti-FOLR antibody |
Information sourced from Uniprot.org