Anti-FNTA antibody (280-379) (STJ111424)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FNTA (280-379) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FNTA |
| Gene ID | 2339 |
| Uniprot ID | FNTA_HUMAN |
| Immunogen Region | 280-379 |
| Immunogen Sequence | LKGILQDRGLSKYPNLLNQL LDLQPSHSSPYLIAFLVDIY EDMLENQCDNKEDILNKALE LCEILAKEKDTIRKEYWRYI GRSLQSKHSTENDSPTNVQQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 280-379 of human FNTA (NP_002018.1). |
Additional Info
| Post Translational Modifications | Phosphorylated. Phosphorylation is mediated by MUSK upon AGRIN stimulation and results in the activation of FNTA. |
| Function | Essential subunit of both the farnesyltransferase and the geranylgeranyltransferase complex. Contributes to the transfer of a farnesyl or geranylgeranyl moiety from farnesyl or geranylgeranyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X. May positively regulate neuromuscular junction development downstream of MUSK via its function in RAC1 prenylation and activation. |
| Protein Name | Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit AlphaCaax Farnesyltransferase Subunit AlphaFtase-AlphaRas Proteins Prenyltransferase Subunit AlphaType I Protein Geranyl-Geranyltransferase Subunit AlphaGgtase-I-Alpha |
| Database Links | Reactome: R-HSA-111465Reactome: R-HSA-2514859Reactome: R-HSA-9648002Reactome: R-HSA-9679191 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Protein Farnesyltransferase/Geranylgeranyltransferase Type-1 Subunit Alpha antibodyAnti-Caax Farnesyltransferase Subunit Alpha antibodyAnti-Ftase-Alpha antibodyAnti-Ras Proteins Prenyltransferase Subunit Alpha antibodyAnti-Type I Protein Geranyl-Geranyltransferase Subunit Alpha antibodyAnti-Ggtase-I-Alpha antibodyAnti-FNTA antibody |
Information sourced from Uniprot.org