Anti-FNDC5 antibody [R09-4J9] (STJA0034320)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human FNDC5
General Information
| Short Description | Rabbit monoclonal anti-FNDC5 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R09-4J9 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FNDC5 |
| Gene ID | 252995 |
| Uniprot ID | FNDC5_HUMAN |
| Immunogen | A synthetic peptide of human FNDC5 |
Additional Info
| Tissue Specificity | Widely expressed, with highest levels in heart. Very low expression, if any, in colon, pancreas and spleen. |
| Post Translational Modifications | The extracellular domain is cleaved and released from the cell membrane. N-Glycosylated. |
| Function | Irisin: Mediates beneficial effects of muscular exercise. Induces browning of white adipose tissue by stimulating UCP1 expression, at least in part, via the nuclear receptor PPARA. |
| Protein Name | Fibronectin Type Iii Domain-Containing Protein 5Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin |
| Database Links | |
| Cellular Localisation | Fibronectin Type Iii Domain-Containing Protein 5: Cell MembraneSingle-Pass Membrane ProteinPeroxisome MembraneImported Into Peroxisomes Through The Pex5 Receptor PathwayIrisin: SecretedDetected In Plasma Following Endurance Exercise |
| Alternative Antibody Names | Anti-Fibronectin Type Iii Domain-Containing Protein 5 antibodyAnti-Fibronectin Type Iii Repeat-Containing Protein 2 Cleaved Into - Irisin antibodyAnti-FNDC5 antibodyAnti-FRCP2 antibody |
Information sourced from Uniprot.org