| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | FNDC4 |
| Gene ID: | 64838 |
| Uniprot ID: | FNDC4_HUMAN |
| Immunogen Region: | 45-167 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-167 of human FNDC4 (NP_073734.1). |
| Immunogen Sequence: | DRPPSPVNVTVTHLRANSAT VSWDVPEGNIVIGYSISQQR QNGPGQRVIREVNTTTRACA LWGLAEDSDYTVQVRSIGLR GESPPGPRVHFRTLKGSDRL PSNSSSPGDITVEGLDGERP LQT |
| Tissue Specificity | Highly expressed in the liver and the brain, including in the cortex, hypothalamus and hippocampus. Also expressed in adipose tissue. |
| Function | Soluble FNDC4: Has anti-inflammatory properties. In the colon, acts on macrophages to down-regulate inflammation. May suppress osteoclastogenesis and mature osteoclast resorptive function. In white adipose tissue, decreases local inflammation, via interaction with GPR116. Also required for proper systemic glucose tolerance, specifically sensitizing white adipocytes to insulin and promoting glucose uptake. The insulin sensitizing function in adipose tissue is mediated by interaction with ADGRF5/GPR116 and activation of cAMP signaling. |
| Protein Name | Fibronectin Type Iii Domain-Containing Protein 4 Fibronectin Type Iii Repeat-Containing Protein 1 Cleaved Into - Soluble Fndc4 Sfndc4 |
| Cellular Localisation | Fibronectin Type Iii Domain-Containing Protein 4: Membrane Single-Pass Type I Membrane Protein Soluble Fndc4: Secreted |
| Alternative Antibody Names | Anti-Fibronectin Type Iii Domain-Containing Protein 4 antibody Anti-Fibronectin Type Iii Repeat-Containing Protein 1 Cleaved Into - Soluble Fndc4 antibody Anti-Sfndc4 antibody Anti-FNDC4 antibody Anti-FRCP1 antibody Anti-UNQ6389 antibody Anti-PRO21134 antibody |
Information sourced from Uniprot.org