Anti-FNBP1L antibody (STJA0004478)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human FNBP1L
General Information
| Short Description | Rabbit polyclonal anti-Formin-Binding Protein 1-Like for use in WB, IHC and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.9 mg/mL |
| Purification | Antigen affinity purification |
| Dilution Range | WB 1:500-1:2000, IHC 1:20-1:100 |
| Formulation | PBS with 0.05% NaN3 and 40% Glycerol, pH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | FNBP1L |
| Gene ID | 54874 |
| Uniprot ID | FBP1L_HUMAN |
| Immunogen | Synthetic peptide of human FNBP1L |
Additional Info
| Function | Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. |
| Protein Name | Formin-Binding Protein 1-LikeTransducer Of Cdc42-Dependent Actin Assembly Protein 1Toca-1 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013409 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic Side |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1-Like antibodyAnti-Transducer Of Cdc42-Dependent Actin Assembly Protein 1 antibodyAnti-Toca-1 antibodyAnti-FNBP1L antibodyAnti-C1orf39 antibodyAnti-TOCA1 antibody |
Information sourced from Uniprot.org