Anti-FNBP1 antibody (STJA0008714)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human FBP17
General Information
| Short Description | Rabbit polyclonal anti-Formin-binding protein 1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FNBP1 |
| Gene ID | 23048 |
| Uniprot ID | FNBP1_HUMAN |
| Immunogen | Synthesized peptide derived from human FBP17 |
| Specificity | This antibody detects endogenous levels of FBP17 at Human, Mouse, Rat |
Additional Info
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Formin-Binding Protein 1Formin-Binding Protein 17Hfbp17 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneClathrin-Coated PitEnriched In Cortical Regions Coincident With F-ActinAlso Localizes To Endocytic Vesicles And Lysosomes |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1 antibodyAnti-Formin-Binding Protein 17 antibodyAnti-Hfbp17 antibodyAnti-FNBP1 antibodyAnti-FBP17 antibodyAnti-KIAA0554 antibody |
Information sourced from Uniprot.org