| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FNBP1 (1-210) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FNBP1 |
| Gene ID: |
23048 |
| Uniprot ID: |
FNBP1_HUMAN |
| Immunogen Region: |
1-210 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-210 of human FNBP1 (NP_055848.1). |
| Immunogen Sequence: |
MSWGTELWDQFDNLEKHTQW GIDILEKYIKFVKERTEIEL SYAKQLRNLSKKYQPKKNSK EEEEYKYTSCKAFISNLNEM NDYAGQHEVISENMASQIIV DLARYVQELKQERKSNFHDG RKAQQHIETCWKQLESSKRR FERDCKEADRAQQYFEKMDA DINVTKADVEKARQQAQIRH QMAEDSKADYSSILQKFNHE QHEYYHTHIP |
| Tissue Specificity | Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain. |
| Function | May act as a link between RND2 signaling and regulation of the actin cytoskeleton. Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during the late stage of clathrin-mediated endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL. |
| Protein Name | Formin-Binding Protein 1Formin-Binding Protein 17Hfbp17 |
| Database Links | Reactome: R-HSA-8856828Reactome: R-HSA-9013148Reactome: R-HSA-9013406Reactome: R-HSA-9013409Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmCytoskeletonCell CortexLysosomeCytoplasmic VesicleCell MembranePeripheral Membrane ProteinCytoplasmic SideMembraneClathrin-Coated PitEnriched In Cortical Regions Coincident With F-ActinAlso Localizes To Endocytic Vesicles And Lysosomes |
| Alternative Antibody Names | Anti-Formin-Binding Protein 1 antibodyAnti-Formin-Binding Protein 17 antibodyAnti-Hfbp17 antibodyAnti-FNBP1 antibodyAnti-FBP17 antibodyAnti-KIAA0554 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
