Anti-FMO1 antibody (371-470) (STJ11105610)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Flavin-Containing Monooxygenase 1 (371-470) antibody for use in WB, IF, ICC and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FMO1 |
| Gene ID | 2326 |
| Uniprot ID | FMO1_HUMAN |
| Immunogen Region | 371-470 |
| Immunogen Sequence | LIKPLGSMIPTGETQARWAV RVLKGVNKLPPPSVMIEEIN ARKENKPSWFGLCYCKALQS DYITYIDELLTYINAKPNLF SMLLTDPHLALTVFFGPCSP |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 371-470 of human FMO1 (NP_002012.1). |
Additional Info
| Tissue Specificity | Expressed mainly in fetal and adult liver. |
| Function | Broad spectrum monooxygenase that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including xenobiotics. Catalyzes the S-oxygenation of hypotaurine to produce taurine, an organic osmolyte involved in cell volume regulation as well as a variety of cytoprotective and developmental processes. In vitro, catalyzes the N-oxygenation of trimethylamine (TMA) to produce trimethylamine N-oxide (TMAO) and could therefore participate to the detoxification of this compound that is generated by the action of gut microbiota from dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. |
| Protein Name | Flavin-Containing Monooxygenase 1Dimethylaniline Monooxygenase N-Oxide-Forming 1Dimethylaniline Oxidase 1Fetal Hepatic Flavin-Containing Monooxygenase 1Fmo 1Trimethylamine Monooxygenase |
| Database Links | Reactome: R-HSA-1614558Reactome: R-HSA-217271 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Flavin-Containing Monooxygenase 1 antibodyAnti-Dimethylaniline Monooxygenase N-Oxide-Forming 1 antibodyAnti-Dimethylaniline Oxidase 1 antibodyAnti-Fetal Hepatic Flavin-Containing Monooxygenase 1 antibodyAnti-Fmo 1 antibodyAnti-Trimethylamine Monooxygenase antibodyAnti-FMO1 antibody |
Information sourced from Uniprot.org