Anti-FLVCR1 antibody (481-530 aa) (STJ192562)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 481-530
General Information
| Short Description | Rabbit polyclonal anti-Heme transporter FLVCR1 (481-530 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FLVCR1 |
| Gene ID | 28982 |
| Uniprot ID | FLVC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 481-530 |
| Immunogen Region | 481-530 aa |
| Specificity | FLVC1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | N-Glycosylated. |
| Function | Uniporter that mediates the transport of extracellular choline and ethanolamine into cells, thereby playing a key role in phospholipid biosynthesis. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Isoform 1: Uniporter that mediates the transport of extracellular choline and ethanolamine into cells. Choline and ethanolamine are the precursors of phosphatidylcholine and phosphatidylethanolamine, respectively, the two most abundant phospholipids. Transport is not coupled with proton transport and is exclusively driven by the choline (or ethanolamine) gradient across the plasma membrane. Also acts as a heme b transporter that mediates heme efflux from the cytoplasm to the extracellular compartment. Heme export depends on the presence of HPX and is required to maintain intracellular free heme balance, protecting cells from heme toxicity. Heme export provides protection from heme or ferrous iron toxicities in liver, brain, sensory neurons and during erythropoiesis, a process in which heme synthesis intensifies. Possibly export coproporphyrin and protoporphyrin IX, which are both intermediate products in the heme biosynthetic pathway. Does not export bilirubin. The molecular mechanism of heme transport, whether electrogenic, electroneutral or coupled to other ions, remains to be elucidated. Isoform 2: Heme b transporter that promotes heme efflux from the mitochondrion to the cytoplasm. Essential for erythroid differentiation. Isoform 1: (Microbial infection) Confers susceptibility to feline leukemia virus subgroup C (FeLV-C) infection in vitro. |
| Protein Name | Choline/Ethanolamine Transporter Flvcr1Feline Leukemia Virus Subgroup C Receptor-Related Protein 1Feline Leukemia Virus Subgroup C ReceptorHflvcrHeme Transporter Flvcr1 |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-917937 Q9Y5Y0-1 |
| Cellular Localisation | Isoform 1: Cell MembraneMulti-Pass Membrane ProteinIsoform 2: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Choline/Ethanolamine Transporter Flvcr1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor-Related Protein 1 antibodyAnti-Feline Leukemia Virus Subgroup C Receptor antibodyAnti-Hflvcr antibodyAnti-Heme Transporter Flvcr1 antibodyAnti-FLVCR1 antibodyAnti-FLVCR antibody |
Information sourced from Uniprot.org