Anti-FLRT2 antibody (170-250 aa) (STJ192439)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 170-250
General Information
| Short Description | Rabbit polyclonal anti-Leucine-rich repeat transmembrane protein FLRT2 (170-250 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FLRT2 |
| Gene ID | 23768 |
| Uniprot ID | FLRT2_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 170-250 |
| Immunogen Region | 170-250 aa |
| Specificity | FLRT2 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. Cleavage is probably effected by a metalloprotease. |
| Function | Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt2Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 |
| Database Links | Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCell JunctionFocal AdhesionSecretedExtracellular SpaceExtracellular MatrixMicrosome MembraneSynapseSynaptosomeProteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Transmembrane Protein Flrt2 antibodyAnti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 2 antibodyAnti-FLRT2 antibodyAnti-KIAA0405 antibodyAnti-UNQ232 antibodyAnti-PRO265 antibody |
Information sourced from Uniprot.org