| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Leucine-rich repeat transmembrane protein FLRT1 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FLRT1 |
| Gene ID: |
23769 |
| Uniprot ID: |
FLRT1_HUMAN |
| Specificity: |
FLRT1 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | N-glycosylated. Phosphorylated in response to FGFR1 signaling, but is not a direct substrate of FGFR1 or SRC. A mutant where the Tyr phosphorylation sites have been replaced by Phe displays constitutive FGFR1-dependent activation of downstream MAP kinases. Proteolytic cleavage in the juxtamembrane region gives rise to a soluble ectodomain. |
| Function | Plays a role in fibroblast growth factor-mediated signaling cascades that lead to the activation of MAP kinases. Promotes neurite outgrowth via FGFR1-mediated activation of downstream MAP kinases. Promotes an increase both in neurite number and in neurite length. May play a role in cell-cell adhesion and cell guidance via its interaction with ADGRL1/LPHN1 and ADGRL3. |
| Protein Name | Leucine-Rich Repeat Transmembrane Protein Flrt1Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 |
| Database Links | Reactome: R-HSA-5654687 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneCytoplasmic Vesicle MembraneCytoplasmPerinuclear RegionCell JunctionFocal AdhesionSecretedCell ProjectionNeuron ProjectionIn Addition To Its Location At The Cell MembraneColocalizes With Fgfr1 In Punctate Perinuclear Cytoplasmic VesiclesDetected Along Neurites And At Contacts Between Neurite Termini And Other CellsProteolytic Cleavage Gives Rise To A Shedded Ectodomain |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Transmembrane Protein Flrt1 antibodyAnti-Fibronectin-Like Domain-Containing Leucine-Rich Transmembrane Protein 1 antibodyAnti-FLRT1 antibodyAnti-UNQ752 antibodyAnti-PRO1483 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
