Anti-FLNC antibody (2160-2340) (STJ114985)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FLNC (2160-2340) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FLNC |
| Gene ID | 2318 |
| Uniprot ID | FLNC_HUMAN |
| Immunogen Region | 2160-2340 |
| Immunogen Sequence | IPGNWFQMVSAQERLTRTFT RSSHTYTRTERTEISKTRGG ETKREVRVEESTQVGGDPFP AVFGDFLGRERLGSFGSITR QQEGEASSQDMTAQVTSPSG KVEAAEIVEGEDSAYSVRFV PQEMGPHTVAVKYRGQHVPG SPFQFTVGPLGEGGAHKVRA GGTGLERGVAGVPAEFSIWT R |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 2160-2340 of human FLNC (NP_001449.3). |
Additional Info
| Tissue Specificity | Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. |
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | Muscle-specific filamin, which plays a central role in sarcomere assembly and organization. Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events. |
| Protein Name | Filamin-CFln-CFlncAbp-280-Like ProteinAbp-LActin-Binding-Like ProteinFilamin-2Gamma-Filamin |
| Database Links | Reactome: R-HSA-446353 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane ProteinCytoskeletonMyofibrilSarcomereZ LineA Small Amount Localizes At MembranesIn Striated Muscle CellsIt Predominantly Localizes In Myofibrillar Z LinesWhile A Minor Fraction Localizes With SubsarcolemmeTargeting To Developing And Mature Z Lines Is Mediated By The Intradomain Insert |
| Alternative Antibody Names | Anti-Filamin-C antibodyAnti-Fln-C antibodyAnti-Flnc antibodyAnti-Abp-280-Like Protein antibodyAnti-Abp-L antibodyAnti-Actin-Binding-Like Protein antibodyAnti-Filamin-2 antibodyAnti-Gamma-Filamin antibodyAnti-FLNC antibodyAnti-ABPL antibodyAnti-FLN2 antibody |
Information sourced from Uniprot.org