Anti-FLG2 antibody (402-452 aa) (STJ195486)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human FILA2 at the amino acid range 402-452
General Information
| Short Description | Rabbit polyclonal anti-Filaggrin-2 (402-452 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FLG2 |
| Gene ID | 388698 |
| Uniprot ID | FILA2_HUMAN |
| Immunogen | Synthesized peptide derived from the human FILA2 at the amino acid range 402-452 |
| Immunogen Region | 402-452 aa |
| Specificity | This antibody detects endogenous levels of FILA2 at Human/Mouse |
Additional Info
| Post Translational Modifications | Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers. |
| Function | Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis. |
| Protein Name | Filaggrin-2Flg-2Intermediate Filament-Associated And Psoriasis-Susceptibility ProteinIfapsoriasin |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | CytoplasmCytoplasmic GranuleIn The Stratum Corneum Of The EpidermisDispersed Diffusely Throughout The CytoplasmWhile In The Stratum GranulosumLocalized Within Keratohyalin GranulesIn Granular Keratinocytes And In Lower CorneocytesColocalizes With Calpain-1/Capn1 |
| Alternative Antibody Names | Anti-Filaggrin-2 antibodyAnti-Flg-2 antibodyAnti-Intermediate Filament-Associated And Psoriasis-Susceptibility Protein antibodyAnti-Ifapsoriasin antibodyAnti-FLG2 antibodyAnti-IFPS antibody |
Information sourced from Uniprot.org