• Western blot analysis of lysates from U2OS cells, primary antibody was diluted at 1:1000, 4°C over night

Anti-FLG2 antibody (402-452 aa) (STJ195486)

SKU:
STJ195486

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Filaggrin-2 (402-452 aa) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FLG2
Gene ID: 388698
Uniprot ID: FILA2_HUMAN
Immunogen Region: 402-452 aa
Specificity: This antibody detects endogenous levels of FILA2 at Human/Mouse
Immunogen: Synthesized peptide derived from the human FILA2 at the amino acid range 402-452
Post Translational Modifications Deiminated by PADI1, PADI2 or PADI3 in vitro. The deiminated form is degraded by calpain-1/CAPN1 more quickly and into shorter peptides than the intact protein. May be processed by calpain-1/CAPN1 in the uppermost epidermal layers.
Function Essential for normal cell-cell adhesion in the cornified cell layers. Important for proper integrity and mechanical strength of the stratum corneum of the epidermis.
Protein Name Filaggrin-2
Flg-2
Intermediate Filament-Associated And Psoriasis-Susceptibility Protein
Ifapsoriasin
Database Links Reactome: R-HSA-6798695
Cellular Localisation Cytoplasm
Cytoplasmic Granule
In The Stratum Corneum Of The Epidermis
Dispersed Diffusely Throughout The Cytoplasm
While In The Stratum Granulosum
Localized Within Keratohyalin Granules
In Granular Keratinocytes And In Lower Corneocytes
Colocalizes With Calpain-1/Capn1
Alternative Antibody Names Anti-Filaggrin-2 antibody
Anti-Flg-2 antibody
Anti-Intermediate Filament-Associated And Psoriasis-Susceptibility Protein antibody
Anti-Ifapsoriasin antibody
Anti-FLG2 antibody
Anti-IFPS antibody

Information sourced from Uniprot.org

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