Anti-FLAP antibody (62-161) [S2MR] (STJ11103062)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal FLAP (62-161) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S2MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALOX5AP |
| Gene ID | 241 |
| Uniprot ID | AL5AP_HUMAN |
| Immunogen Region | 62-161 |
| Immunogen Sequence | DAYPTFLAVLWSAGLLCSQV PAAFAGLMYLFVRQKYFVGY LGERTQSTPGYIFGKRIILF LFLMSVAGIFNYYLIFFFGS DFENYIKTISTTISPLLLIP |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 62-161 of human FLAP (P20292). |
Additional Info
| Function | Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes. |
| Protein Name | Arachidonate 5-Lipoxygenase-Activating ProteinFlapMk-886-Binding Protein |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142691Reactome: R-HSA-2142700 |
| Cellular Localisation | Nucleus MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Arachidonate 5-Lipoxygenase-Activating Protein antibodyAnti-Flap antibodyAnti-Mk-886-Binding Protein antibodyAnti-ALOX5AP antibodyAnti-FLAP antibody |
Information sourced from Uniprot.org