| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-FKBP38 (1-100) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S8MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FKBP8 |
| Gene ID: |
23770 |
| Uniprot ID: |
FKBP8_HUMAN |
| Immunogen Region: |
1-100 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human FKBP38/FKBP8 (Q14318). |
| Immunogen Sequence: |
MASCAEPSEPSAPLPAGVPP LEDFEVLDGVEDAEGEEEEE EEEEEEDDLSELPPLEDMGQ PPAEEAEQPGALAREFLAAM EPEPAPAPAPEEWLDILGNG |
| Tissue Specificity | Widely expressed. Highest levels seen in the brain. Highly abundant in the retina. |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis. Involved in the inhibition of viral infection by influenza A viruses (IAV). |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8Ppiase Fkbp838 Kda Fk506-Binding Protein38 Kda FkbpFkbp-38Hfkbp38Fk506-Binding Protein 8Fkbp-8Fkbpr38Rotamase |
| Database Links | Reactome: R-HSA-5689880 |
| Cellular Localisation | MitochondrionMitochondrion MembraneSingle-Pass Membrane ProteinCytoplasmic SideIsoform 1: Mitochondrion MembraneIsoform 3: Mitochondrion Membrane |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp8 antibodyAnti-Ppiase Fkbp8 antibodyAnti-38 Kda Fk506-Binding Protein antibodyAnti-38 Kda Fkbp antibodyAnti-Fkbp-38 antibodyAnti-Hfkbp38 antibodyAnti-Fk506-Binding Protein 8 antibodyAnti-Fkbp-8 antibodyAnti-Fkbpr38 antibodyAnti-Rotamase antibodyAnti-FKBP8 antibodyAnti-FKBP38 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunoprecipitation analysis of 600 Mu g extracts of 293T cells using 3 Mu g [KD Validated] CDX2 Rabbit monoclonal antibody (STJ11101568). Western blot was performed from the immunoprecipitate using CDX2 antibody (STJ11101568) at a dilution of 1:500.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/90481/359933/STJ11101568_1__84936.1713124490.jpg?c=1 "Immunoprecipitation analysis of 600 Mu g extracts of 293T cells using 3 Mu g [KD Validated] CDX2 Rabbit monoclonal antibody (STJ11101568). Western blot was performed from the immunoprecipitate using CDX2 antibody (STJ11101568) at a dilution of 1:500.")
