Anti-FKBP52 antibody [R03-4A3] (STJA0034317)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human FKBP52
General Information
| Short Description | Rabbit monoclonal anti-FKBP52 for use in WB, ICC and IF in Human, Mouse, Rat and Hamster samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Hamster |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-4A3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IF 1:50-1:200 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FKBP4 |
| Gene ID | 2288 |
| Uniprot ID | FKBP4_HUMAN |
| Immunogen | A synthetic peptide of human FKBP52 |
Additional Info
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation by CK2 results in loss of HSP90 binding activity. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Also acts as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4Ppiase Fkbp451 Kda Fk506-Binding ProteinFkbp5152 Kda Fk506-Binding Protein52 Kda FkbpFkbp-5259 Kda ImmunophilinP59Fk506-Binding Protein 4Fkbp-4Fkbp59Hsp-Binding ImmunophilinHbiImmunophilin Fkbp52Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-3371568Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | CytoplasmCytosolMitochondrionNucleusCytoskeletonCell ProjectionAxonShuttles From Mitochondria To NucleusCo-Localizes In Mitochondria With The Glucocorticoid ReceptorColocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 antibodyAnti-Ppiase Fkbp4 antibodyAnti-51 Kda Fk506-Binding Protein antibodyAnti-Fkbp51 antibodyAnti-52 Kda Fk506-Binding Protein antibodyAnti-52 Kda Fkbp antibodyAnti-Fkbp-52 antibodyAnti-59 Kda Immunophilin antibodyAnti-P59 antibodyAnti-Fk506-Binding Protein 4 antibodyAnti-Fkbp-4 antibodyAnti-Fkbp59 antibodyAnti-Hsp-Binding Immunophilin antibodyAnti-Hbi antibodyAnti-Immunophilin Fkbp52 antibodyAnti-Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed antibodyAnti-FKBP4 antibodyAnti-FKBP52 antibody |
Information sourced from Uniprot.org