Anti-FKBP5 antibody (STJ192312)

SKU:
STJ192312

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Peptidyl-prolyl cis-trans isomerase FKBP5 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FKBP5
Gene ID: 2289
Uniprot ID: FKBP5_HUMAN
Specificity: FKBP5 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation.
Function Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5
Ppiase Fkbp5
51 Kda Fk506-Binding Protein
51 Kda Fkbp
Fkbp-51
54 Kda Progesterone Receptor-Associated Immunophilin
Androgen-Regulated Protein 6
Ff1 Antigen
Fk506-Binding Protein 5
Fkbp-5
Fkbp54
P54
Hsp90-Binding Immunophilin
Rotamase
Database Links Reactome: R-HSA-3371497
Reactome: R-HSA-8939211
Reactome: R-HSA-9022699
Cellular Localisation Cytoplasm
Nucleus
Alternative Antibody Names Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 antibody
Anti-Ppiase Fkbp5 antibody
Anti-51 Kda Fk506-Binding Protein antibody
Anti-51 Kda Fkbp antibody
Anti-Fkbp-51 antibody
Anti-54 Kda Progesterone Receptor-Associated Immunophilin antibody
Anti-Androgen-Regulated Protein 6 antibody
Anti-Ff1 Antigen antibody
Anti-Fk506-Binding Protein 5 antibody
Anti-Fkbp-5 antibody
Anti-Fkbp54 antibody
Anti-P54 antibody
Anti-Hsp90-Binding Immunophilin antibody
Anti-Rotamase antibody
Anti-FKBP5 antibody
Anti-AIG6 antibody
Anti-FKBP51 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance