| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FKBP5 (308-457) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FKBP5 |
| Gene ID: |
2289 |
| Uniprot ID: |
FKBP5_HUMAN |
| Immunogen Region: |
308-457 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 308-457 of human FKBP51/FKBP51/FKBP51/FKBP5 (NP_001139247.1). |
| Immunogen Sequence: |
ESKASESFLLAAFLNLAMCY LKLREYTKAVECCDKALGLD SANEKGLYRRGEAQLLMNEF ESAKGDFEKVLEVNPQNKAA RLQISMCQKKAKEHNERDRR IYANMFKKFAEQDAKEEANK AMGKKTSEGVTNEKGTDSQA MEEEKPEGHV |
| Tissue Specificity | Widely expressed, enriched in testis compared to other tissues. |
| Post Translational Modifications | Acetylation impairs ability to promote interaction between Akt/AKT1 and PHLPP1. Deacetylation by SIRT7 promotes interaction between Akt/AKT1 and PHLPP1, leading to suppress Akt/AKT1 activation. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of unligated steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). Plays a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors maintaining the complex into the cytoplasm when unliganded. Acts as a regulator of Akt/AKT1 activity by promoting the interaction between Akt/AKT1 and PHLPP1, thereby enhancing dephosphorylation and subsequent activation of Akt/AKT1. Interacts with IKBKE and IKBKB which facilitates IKK complex assembly leading to increased IKBKE and IKBKB kinase activity, NF-kappaB activation, and IFN production. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5Ppiase Fkbp551 Kda Fk506-Binding Protein51 Kda FkbpFkbp-5154 Kda Progesterone Receptor-Associated ImmunophilinAndrogen-Regulated Protein 6Ff1 AntigenFk506-Binding Protein 5Fkbp-5Fkbp54P54Hsp90-Binding ImmunophilinRotamase |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-8939211Reactome: R-HSA-9022699 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp5 antibodyAnti-Ppiase Fkbp5 antibodyAnti-51 Kda Fk506-Binding Protein antibodyAnti-51 Kda Fkbp antibodyAnti-Fkbp-51 antibodyAnti-54 Kda Progesterone Receptor-Associated Immunophilin antibodyAnti-Androgen-Regulated Protein 6 antibodyAnti-Ff1 Antigen antibodyAnti-Fk506-Binding Protein 5 antibodyAnti-Fkbp-5 antibodyAnti-Fkbp54 antibodyAnti-P54 antibodyAnti-Hsp90-Binding Immunophilin antibodyAnti-Rotamase antibodyAnti-FKBP5 antibodyAnti-AIG6 antibodyAnti-FKBP51 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
