| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FKBP4 (220-459) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000IHC-P 1:50-1:200IF/ICC 1:50-1:100IP 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FKBP4 |
| Gene ID: |
2288 |
| Uniprot ID: |
FKBP4_HUMAN |
| Immunogen Region: |
220-459 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-459 of human FKBP52/FKBP52/FKBP4 (NP_002005.1). |
| Immunogen Sequence: |
YLKPSYAFGSVGKEKFQIPP NAELKYELHLKSFEKAKESW EMNSEEKLEQSTIVKERGTV YFKEGKYKQALLQYKKIVSW LEYESSFSNEEAQKAQALRL ASHLNLAMCHLKLQAFSAAI ESCNKALELDSNNEKGLFRR GEAHLAVNDFELARADFQKV LQLYPNNKAAKTQLAVCQQR IRRQLAREKKLYANMFERLA EEENKAKAEASSGDHPTDTE MKEEQKSNTAGSQSQVETE |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylation by CK2 results in loss of HSP90 binding activity. |
| Function | Immunophilin protein with PPIase and co-chaperone activities. Component of steroid receptors heterocomplexes through interaction with heat-shock protein 90 (HSP90). May play a role in the intracellular trafficking of heterooligomeric forms of steroid hormone receptors between cytoplasm and nuclear compartments. The isomerase activity controls neuronal growth cones via regulation of TRPC1 channel opening. Acts also as a regulator of microtubule dynamics by inhibiting MAPT/TAU ability to promote microtubule assembly. May have a protective role against oxidative stress in mitochondria. |
| Protein Name | Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4Ppiase Fkbp451 Kda Fk506-Binding ProteinFkbp5152 Kda Fk506-Binding Protein52 Kda FkbpFkbp-5259 Kda ImmunophilinP59Fk506-Binding Protein 4Fkbp-4Fkbp59Hsp-Binding ImmunophilinHbiImmunophilin Fkbp52Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-3371497Reactome: R-HSA-3371568Reactome: R-HSA-8939211Reactome: R-HSA-9018519Reactome: R-HSA-9679191 |
| Cellular Localisation | CytoplasmCytosolMitochondrionNucleusCytoskeletonCell ProjectionAxonShuttles From Mitochondria To NucleusCo-Localizes In Mitochondria With The Glucocorticoid ReceptorColocalized With Mapt/Tau In The Distal Part Of The Primary Cortical Neurons |
| Alternative Antibody Names | Anti-Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 antibodyAnti-Ppiase Fkbp4 antibodyAnti-51 Kda Fk506-Binding Protein antibodyAnti-Fkbp51 antibodyAnti-52 Kda Fk506-Binding Protein antibodyAnti-52 Kda Fkbp antibodyAnti-Fkbp-52 antibodyAnti-59 Kda Immunophilin antibodyAnti-P59 antibodyAnti-Fk506-Binding Protein 4 antibodyAnti-Fkbp-4 antibodyAnti-Fkbp59 antibodyAnti-Hsp-Binding Immunophilin antibodyAnti-Hbi antibodyAnti-Immunophilin Fkbp52 antibodyAnti-Rotamase Cleaved Into - Peptidyl-Prolyl Cis-Trans Isomerase Fkbp4 - N-Terminally Processed antibodyAnti-FKBP4 antibodyAnti-FKBP52 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
