Anti-FIG4 antibody [R02-4C6] (STJA0035034)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human FIG4
General Information
| Short Description | Rabbit monoclonal anti-FIG4 for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R02-4C6 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | FIG4 |
| Gene ID | 9896 |
| Uniprot ID | FIG4_HUMAN |
| Immunogen | A synthetic peptide of human FIG4 |
Additional Info
| Function | Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. |
| Protein Name | Polyphosphoinositide Phosphatase Phosphatidylinositol 3 -5-Bisphosphate 5-PhosphataseSac Domain-Containing Protein 3Serine-Protein Phosphatase Fig4 |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome MembraneLocalization Requires Vac14 And Pikfyve |
| Alternative Antibody Names | Anti-Polyphosphoinositide Phosphatase antibodyAnti-Phosphatidylinositol 3 -5-Bisphosphate 5-Phosphatase antibodyAnti-Sac Domain-Containing Protein 3 antibodyAnti-Serine-Protein Phosphatase Fig4 antibodyAnti-FIG4 antibodyAnti-KIAA0274 antibodyAnti-SAC3 antibody |
Information sourced from Uniprot.org