Anti-FIG4 antibody (608-907) (STJ117567)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal FIG4 (608-907) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | FIG4 |
| Gene ID | 9896 |
| Uniprot ID | FIG4_HUMAN |
| Immunogen Region | 608-907 |
| Immunogen Sequence | WELPTDFYLHHKNTMRLLPT RRSYTYWWTPEVIKHLPLPY DEVICAVNLKKLIVKKFHKY EEEIDIHNEFFRPYELSSFD DTFCLAMTSSARDFMPKTVG IDPSPFTVRKPDETGKSVLG NKSNREEAVLQRKTAASAPP PPSEEAVSSSSEDDSGTDRE EEGSVSQRSTPVKMTDAGDS AKVTENVVQPMKELYGINLS DGLSEEDFSIYSRFVQLGQS QHKQDKNSQQPCSRCSDGV |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 608-907 of human FIG4 (NP_055660.1). |
Additional Info
| Function | Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. |
| Protein Name | Polyphosphoinositide Phosphatase Phosphatidylinositol 3 -5-Bisphosphate 5-PhosphataseSac Domain-Containing Protein 3Serine-Protein Phosphatase Fig4 |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome MembraneLocalization Requires Vac14 And Pikfyve |
| Alternative Antibody Names | Anti-Polyphosphoinositide Phosphatase antibodyAnti-Phosphatidylinositol 3 -5-Bisphosphate 5-Phosphatase antibodyAnti-Sac Domain-Containing Protein 3 antibodyAnti-Serine-Protein Phosphatase Fig4 antibodyAnti-FIG4 antibodyAnti-KIAA0274 antibodyAnti-SAC3 antibody |
Information sourced from Uniprot.org