| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-FIG4 (608-907) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
FIG4 |
| Gene ID: |
9896 |
| Uniprot ID: |
FIG4_HUMAN |
| Immunogen Region: |
608-907 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 608-907 of human FIG4 (NP_055660.1). |
| Immunogen Sequence: |
WELPTDFYLHHKNTMRLLPT RRSYTYWWTPEVIKHLPLPY DEVICAVNLKKLIVKKFHKY EEEIDIHNEFFRPYELSSFD DTFCLAMTSSARDFMPKTVG IDPSPFTVRKPDETGKSVLG NKSNREEAVLQRKTAASAPP PPSEEAVSSSSEDDSGTDRE EEGSVSQRSTPVKMTDAGDS AKVTENVVQPMKELYGINLS DGLSEEDFSIYSRFVQLGQS QHKQDKNSQQPCSRCSDGV |
| Function | Dual specificity phosphatase component of the PI(3,5)P2 regulatory complex which regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Catalyzes the dephosphorylation of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) to form phosphatidylinositol 3-phosphate. Has serine-protein phosphatase activity acting on PIKfyve to stimulate its lipid kinase activity, its catalytically activity being required for maximal PI(3,5)P2 production. In vitro, hydrolyzes all three D5-phosphorylated polyphosphoinositide and although displaying preferences for PtdIns(3,5)P2, it is capable of hydrolyzing PtdIns(3,4,5)P3 and PtdIns(4,5)P2, at least in vitro. |
| Protein Name | Polyphosphoinositide Phosphatase Phosphatidylinositol 3 -5-Bisphosphate 5-PhosphataseSac Domain-Containing Protein 3Serine-Protein Phosphatase Fig4 |
| Database Links | Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517 |
| Cellular Localisation | Endosome MembraneLocalization Requires Vac14 And Pikfyve |
| Alternative Antibody Names | Anti-Polyphosphoinositide Phosphatase antibodyAnti-Phosphatidylinositol 3 -5-Bisphosphate 5-Phosphatase antibodyAnti-Sac Domain-Containing Protein 3 antibodyAnti-Serine-Protein Phosphatase Fig4 antibodyAnti-FIG4 antibodyAnti-KIAA0274 antibodyAnti-SAC3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
