• STJ73376 (0. 3µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-fibrinogen beta chain antibody (Internal) (STJ73376)

SKU:
STJ73376-100

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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-fibrinogen beta chain (Internal) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: FGB
Gene ID: 2244
Uniprot ID: FIBB_HUMAN
Immunogen Region: Internal
Accession Number: NP_005132.2; NP_001171670.1
Specificity: This antibody is expected to recognize both reported isoforms (NP_005132.2; NP_001171670.1).
Immunogen Sequence: RSKIQKLESDVSAQ
Post Translational Modifications Conversion of fibrinogen to fibrin is triggered by thrombin, which cleaves fibrinopeptides A and B from alpha and beta chains, and thus exposes the N-terminal polymerization sites responsible for the formation of the soft clot. The soft clot is converted into the hard clot by factor XIIIA which catalyzes the epsilon-(gamma-glutamyl)lysine cross-linking between gamma chains (stronger) and between alpha chains (weaker) of different monomers.
Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Protein Name Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-1236974
Reactome: R-HSA-140875
Reactome: R-HSA-166058
Reactome: R-HSA-216083
Reactome: R-HSA-354192
Reactome: R-HSA-354194
Reactome: R-HSA-372708
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Reactome: R-HSA-5674135
Reactome: R-HSA-5686938
Reactome: R-HSA-6802946
Reactome: R-HSA-6802948
Reactome: R-HSA-6802952
Reactome: R-HSA-6802955
Reactome: R-HSA-9649948
Reactome: R-HSA-9656223
Cellular Localisation Secreted
Alternative Antibody Names Anti-Fibrinogen Beta Chain Cleaved Into - Fibrinopeptide B - Fibrinogen Beta Chain antibody
Anti-FGB antibody

Information sourced from Uniprot.org

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